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KMID : 0378019740170121731
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New Medical Journal
1974 Volume.17 No. 12 p.1731 ~ p.1742
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Experimental Studies On The Growth Of Rabbits Incisors Influenced Of Antibiotics & Anti-Inflammatory Agents
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Abstract
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The author has observed on effects of tooth growth, change of body temperature, change of peri￢pheral blood picture & histo-pathological findings injecting various antibiotics & anti-inflammatory agents to rabbits weighing about 2 kg.
A. The speed of tooth growth was the distance from point right up gingival edge on labial side of rabbits´ incisors to new point at same portion every 5 days made by dental sharp burs. The fore￢going 2 points were calculated 1f 100mm micromotor by compus, and it´s average number was the speed of daily tooth growth.
B.
1) Control group
2) Daily oxytetracycline 60mg injected group
3) Daily penicillin 40,000 unit injected group
4) Daily chloramphenicol 100mg injected group
5) Daily streptomycin 40mg injected group
6) Daily sulxin 20mg injected group
7) Daily chymotrypsin 2,500 unit injected group
Control group was not injected by any kind of agents. Group 2, 3, 4, 5, 6, & 7 were not injected by any agents first for 10 days, but injected every day to study tooth growth after 10 days.
C. It weighed the change of body weight before and after injection of agents; to rabbits, measured body temperature every day, and compared the change of blood picture following long termed high dosage injection of agents to rabbits with that of control group.
D. At the end of experiment the animals were decapitated by air injection. Upper and lower
incisors removed from rabbits were fixed 10 per cent formalin, treated ´by the usual paraffin technique, and stained hematoxylin-eosin and Van Gieson.
1. The tooth growth inhibited markedly at long termed high dosage injection of antibiotics-oxytet￢racycline, penicillin, chloramphenicol, & streptomycin-& anti-inflammatory agents- sulxin & chymot￢rypsin.
2. The most inhibitory agents of tooth growth was oxytetracycline, and in turn, sulxin, streptomy￢cin, chloramphenicol, penicillin, & chymotrypsin.
3. Long termed injection of agents-oxytetracycline, penicillin, chloramphenicol, streptomycin, sulxin, & chymotrypsin-decreased body temperature slightly.
4. Long termed injection of agents-oxytetracycline, penicillin, chloramphenicol, streptomycin, sulxin, & chymotrypsin-decreased mostly in. leukocytes (neutrophiles, monocytes, lymphocytes, etc. ), hemoglobin.
5. It showed cloudy pictures of hypo- and hypercalcified dentine due to cumulative penetrated action of agents on odontoblasts. These pictures marked the most in oxytetracycline injected rabbits.
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